Chang KJ, Zollinger DR, Susuki K, Sherman DL, Makara MA, Brophy PJ, Cooper EC, Bennett V, Mohler PJ, Rasband MN. Glial ankyrins facilitate paranodal axoglial junction assembly. Nat Neurosci. 2014 Dec; 17(12):1673-81.  Abstract

 

Ho TS, Zollinger DR, Chang KJ, Xu M, Cooper EC, Stankewich MC, Bennett V, Rasband MN. A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. Nat Neurosci. 2014 Dec; 17(12):1664-72.  Abstract

 

Kole MH, Cooper EC. Axonal Kv7.2/7.3 channels: Caught in the act. Channels (Austin). 2014 Jul 1; 8(4):288-9.  Abstract

 

Kang S, Xu M, Cooper EC, Hoshi N. Channel anchored protein kinase CK2 and protein phosphatase 1 reciprocally regulate KCNQ2-containing M-channels via phosphorylation of calmodulin. J Biol Chem. 2014 Mar 13. Abstract

 

Battefeld A, Tran BT, Gavrilis J, Cooper EC, Kole MH. Heteromeric kv7.2/7.3 channels differentially regulate action potential initiation and conduction in neocortical myelinated axons. J Neurosci. 2014 Mar 5;34(10):3719-32. PDF

 

Millichap JJ and Cooper EC.  KCNQ2 Potassium Channel Epileptic Encephalopathy Syndrome: Divorce of an Electro-Mechanical Couple?  Epilepsy Currents  (2012) 12:150–152. PDF

 

Cooper EC Made for "anchorin": Kv7.2/7.3 (KCNQ2/KCNQ3) channels and the modulation of neuronal excitability in vertebrate axons. Semin Cell Dev Biol. (2011) 22:185-192. PDF

 

Raol YH, Lapides DA, Keating JG, Brooks-Kayal AR, Cooper EC. A KCNQ channel opener for experimental neonatal seizures and status epilepticus. Ann Neurol. (2009) 65:326-336. PDF

 

 

Hill AS, Nishino A, Nakajo K, Zhang G, Fineman JR, Selzer ME, Okamura Y, Cooper EC. Ion channel clustering at the axon initial segment and node of Ranvier evolved sequentially in early chordates. PLoS Genet. (2008) 4:e1000317. PDF

 

Shah MM, Migliore M, Valencia I, Cooper EC, Brown DA. Functional significance of axonal Kv7 channels in hippocampal pyramidal neurons. Proc Natl Acad Sci U S A. (2008) 105:7869-7874. PDF

 

Pan Z, Kao T, Horvath Z, Lemos J, Sul JY, Cranstoun SD, Bennett V, Scherer SS, Cooper EC. A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. J Neurosci. (2006) 26:2599-2613. PDF

 

Schwarz JR, Glassmeier G, Cooper EC, Kao TC, Nodera H, Tabuena D, Kaji R, Bostock H. KCNQ channels mediate IKs, a slow K+ current regulating excitability in the rat node of Ranvier. J Physiol. (2006) 573:17-34. PDF

 

Surti TS, Huang L, Jan YN, Jan LY, Cooper EC. Identification by mass spectrometry and functional characterization of two phosphorylation sites of KCNQ2/KCNQ3 channels. Proc Natl Acad Sci U S A. (2005) 102:17828-33. PDF

 

Devaux JJ, Kleopa KA, Cooper EC, Scherer SS. KCNQ2 is a nodal K+ channel. J Neurosci. (2004) 24:1236-44. PDF

 

Cooper EC, Jan LY. M-channels: neurological diseases, neuromodulation, and drug development. Arch Neurol. (2003) 60:496-500. PDF

 

Cooper EC, Harrington E, Jan YN, Jan LY. M channel KCNQ2 subunits are localized to key sites for control of neuronal network oscillations and synchronization in mouse brain. J Neurosci. (2001) 21:9529-40. PDF

 

Cooper EC, Aldape KD, Abosch A, Barbaro NM, Berger MS, Peacock WS, Jan YN, Jan LY. Colocalization and coassembly of two human brain M-type potassium channel subunits that are mutated in epilepsy. Proc Natl Acad Sci U S A. (2000) 97:4914-9. PDF

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Bringing KCNQ2 Families Together:

 

 

 

 

 

The Jack Pribaz Foundation

The RIKEE Network:

 

 

 

 

 

KCNQ2 in the clinic

© 2013-2015  Edward C. Cooper All rights reserved